Endocrine Abstracts

Background: AMH represents a marker of ovarian reserve and is used in monitoring the effects of gonadotoxic drugs. In PCOS is higher and is an indirect marker of hyperandrogenism. In transsexual man(TM), high prevalence of PCOS is described and AMH provide information about ovarian reserve after exposure to testosterone.Objective: To assess the prevalence of PCOS in young TM previously to testosterone treatment, study the evolution of AMH levels and diff...

Amongst the different markers of ovarian function, AMH levels and antral follicle count (AFC) are the most objective and reliable predictors of ovarian response in women undergoing in-vitro fertilisation (IVF). Several factors, that have been reported to interfere with ovarian response, are taken into consideration when enrolling women into an IVF programme.The aim of this prospective study was to determine the correlation, if any, between baseline AMH l...

Environmental pollution by microplastics has been transcending usual stakeholders (such as policymakers and scientists) to become a public concern. The conspicuous, widespread occurrence of (micro)plastics together with the publicization by the media of its potential impacts on wildlife and human health have contributed for this state of affairs. Microplastics, typically defined as plastic particles smaller than 5 mm, have been detected throughout the marine, freshwater and te...

The evidence base for starting early insulin treatment in patients with type 2 diabetes is rather scanty. In the UKPDS trial the intensive treatment of hyperglycaemia in newly detected patients with type 2 diabetes based on insulin or sulponylurea (no separation possible) revealed a significant reduction of myocardial infarction risk (15%, P=0.01), but only after prolonged post-study follow-up after 10 years1. In 2012 the ORIGIN study was published showing ...

We have uncovered the entire functional oxytocin (OT) system in the rat and human heart. In the experimentally-induced myocardial infarction (MI) in rats, the continuous OT delivery improves the cardiac work, reduces inflammation, and stimulates angiogenesis. We hypothesized that these actions of OT are mediated by increase in glucose uptake in cardiomyocytes (CM). Indeed OT (10 nM) increased basal glucose uptake in CM to 4.0±0.2 fmol/mg protein in comparison to 2.2 fmol/...

Autoimmune thyroiditis (AIT) is a group of inflammatory thyroid disorders with either hyperthyroid, euthyroid or hypothyroid state. The aim of this study is to detect the subclinical thyroiditis among the Egyptians type 1 diabetic patients and to study the relation of the thyroid antibodies to different metabolic control indices of diabetes. The study group consisted of 50 type 1 diabetic patients aged from 8 to 18 years. They were selected from the out-patient daily clinics o...

Objective: To examine immunoglobulin concentrations in the sera of children with type 1 diabetes and to compare them with those found in non-diabetic subjects.Patients and Method: Serum immunoglobulin A and D concentrations were measured by ELISA in 35 children with type 1 diabetes and 46 healthy children (younger than 15 years of age).Results: Serum immunoglobulin levels increase until the age of 15 but no sex variation has been found. Age variation of the mean immuno...

Despite the known health hazards of cigarette smoking, many smokers fail to quit smoking, mainly due to nicotine’s addictiveness, but also because of fear from gaining weight. However, the mechanism of weight gain after smoking cessation is not fully elucidated yet.Healthy long-term smokers (28±2 years, 10F/20M, 23.4±1.3 kg/m2) participating in a smoking cessation programme underwent 3-hour oral glucose tolerance tests (oGTT) an...

Introduction: Iodine deficiency is a common problem of public health that usually causes thyroid enlargement called goiter. It is estimated that 750 million people worldwide are at risk of Iodine Deficiency Disorders (IDD). IDD can be presented with a wide variety of clinical manifestations, which induce congenital anomalies, cretinism, deaf mutism, psychomotor defects and severe goiter.About 17 years after the initiation of salt iodization in Iran, this...

M O Thorner, University of Virginia, Charlottesville, VA, USA AbstractMichael O. Thorner is David C. Harrison Teaching Professor of Internal Medicine. He previously was Kenneth R. Cripsell Professor, Chief of the Division of Endocrinology and Director of the General Clinical Research Center and Henry B Mulholland Professor and Chair, Department of Internal Medicine at the University of Virginia. He is a fellow of the A...